Research application
Immune profiling
Research analysis of clone expansion/persistence, memory/activation/dysfunction states, comparison of cell products and later samples, repeated-measures comparisons. Scope is agreed after reviewing laboratory-generated data, study design and feasibility.
Analyses are tailored to your experimental design, data quality and research question. The workflow and deliverables are agreed following project review.
Analysis modules
Repertoire QC: assess receptor recovery and matched donor/time annotations.
Clone monitoring: summarize expansion and persistence across sampled time points.
Cell-state comparisons: examine memory, activation and dysfunction programmes.
Product-to-sample integration: distinguish engineered cells only when the assay supports identification.
Repeated-measures analysis: compare trajectories while accounting for donor, time and missing samples.
Data and metadata
ScRNA/TCR, flow cytometry and time-point/donor metadata; distinguish engineered cells only when assay supports it. Include assay and processing provenance, quality-control summaries, sample identifiers without patient identifiers, species/tissue, groups, controls, batch and relevant donor/time-point metadata.
Proposed deliverables
Clone trajectories, phenotype tables, longitudinal figures. Proposed outputs include documented methods, quality-control summaries and explicit limitations; deliverables are tailored after review.
Interpretation and feasibility
No clinical efficacy/toxicity prediction claims.
Selected scientific references
Selected methodological and research references. Methods and software are chosen for each project after feasibility and licence review. Citations do not imply affiliation or validation of an ImmunLattice pipeline.
CELLFIE (Nature 2025). Research context for cellular perturbation and therapy.
AIRR Community recommendations for sharing immune-repertoire sequencing data (Nature Immunology 2017). Data-sharing and repertoire metadata guidance.
Functional diversification and dynamics of CAR-T cells in patients with B-ALL (Cell Reports 2023). Research application: longitudinal single-cell profiling of CAR-T states after infusion in B-ALL.
Durable response to CAR T is associated with elevated activation and clonotypic expansion of the cytotoxic native T cell repertoire (Nature Communications 2025). Research application: combines longitudinal immune profiling with native T-cell clonotype expansion after CD19 CAR-T therapy.
Lineage tracing reveals clonal progenitors and long-term persistence of tumor-specific T cells during immune checkpoint blockade (Cancer Cell 2023). Research application: tracks persistent tumour-specific T-cell clones across tissues and time during checkpoint blockade.
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