Research application
Immune profiling
Research analysis of response kinetics, clone persistence, B-cell lineages and associations of early signatures with measured durable responses. Scope is agreed after reviewing laboratory-generated data, study design and feasibility.
Analyses are tailored to your experimental design, data quality and research question. The workflow and deliverables are agreed following project review.
Analysis modules
Longitudinal QC: assess donor matching, sampling intervals and assay coverage.
Response kinetics: compare measured repertoire, expression, cytometry or serology time courses.
Clone persistence: summarize observed persistence over suitable follow-up.
B-cell lineages: reconstruct supported lineage relationships without inferring affinity from mutation.
Durability associations: relate early signatures to measured later responses, not vaccine efficacy.
Data and metadata
Longitudinal repertoire/transcriptomic/cytometry/serology data. Include assay and processing provenance, quality-control summaries, sample identifiers without patient identifiers, species/tissue, groups, controls, batch and relevant donor/time-point metadata.
Proposed deliverables
Time-course plots, clonal lineage summaries and associations. Proposed outputs include documented methods, quality-control summaries and explicit limitations; deliverables are tailored after review.
Interpretation and feasibility
Sequence mutation does not establish affinity; durability requires suitable follow-up; no efficacy claim.
Selected scientific references
Selected methodological and research references. Methods and software are chosen for each project after feasibility and licence review. Citations do not imply affiliation or validation of an ImmunLattice pipeline.
Antibody-response durability across vaccines (Nature Immunology 2025). Follow-up and measured response durability.
AIRR Community recommendations for sharing immune-repertoire sequencing data (Nature Immunology 2017). Data-sharing and repertoire metadata guidance.
Tracking B cell responses to the SARS-CoV-2 mRNA-1273 vaccine (Cell Reports 2023). Research application: combines BCR sequences, RNA and surface proteins to track vaccine-induced B-cell clones over time.
Two distinct durable human class-switched memory B cell populations are induced by vaccination and infection (Cell Reports 2025). Research application: distinguishes durable human memory B-cell populations after vaccination and infection.
Distinct components of mRNA vaccines cooperate to instruct efficient germinal center responses (Cell 2025). Research application: dissects mRNA and lipid-nanoparticle contributions to dendritic-cell, Tfh and germinal-centre responses.
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