Research application
Genomics & regulation
Compare priming and restimulation, chromatin accessibility/regulatory programmes and linked functional responses. Scope is agreed after reviewing laboratory-generated data, study design and feasibility.
Analyses are tailored to your experimental design, data quality and research question. The workflow and deliverables are agreed following project review.
Analysis modules
Design review: assess controlled priming, restimulation and replication.
RNA contrasts: compare transcriptional responses across supported conditions.
Chromatin contrasts: summarize accessibility or histone-mark changes.
Regulatory integration: connect region annotations and pathway programmes.
Functional context: compare linked measured responses; omics alone does not establish trained immunity.
Data and metadata
RNA, ATAC or histone-mark profiles with controlled training/restimulation design. Include assay and processing provenance, quality-control summaries, sample identifiers without patient identifiers, species/tissue, groups, controls, batch and relevant donor/time-point metadata.
Proposed deliverables
Regulatory region tables, pathway summaries and condition contrasts. Proposed outputs include documented methods, quality-control summaries and explicit limitations; deliverables are tailored after review.
Interpretation and feasibility
Omics alone does not establish functional trained immunity.
Selected scientific references
Selected methodological and research references. Methods and software are chosen for each project after feasibility and licence review. Citations do not imply affiliation or validation of an ImmunLattice pipeline.
Histone lactylation and innate immune memory (Cell 2025). Research context for regulatory and functional memory.
ATAC-seq (Nature Methods 2013). Chromatin accessibility assay methodology.
Epigenetic memory of coronavirus infection in innate immune cells and their progenitors (Cell 2023). Research application: integrates epigenomic and transcriptomic evidence of persistent innate-cell and progenitor changes after infection.
BCG vaccination in humans elicits trained immunity via the hematopoietic progenitor compartment (Cell Host & Microbe 2020). Foundational application: links human BCG vaccination to persistent progenitor and monocyte programmes using paired molecular profiling.
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